How THC And CBD Work Together

How THC And CBD Work Together

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You must have heard about the entourage effect. If you look a bit closer at how cannabis works, you often come across this term. You probably also know that THC and CBD work together. They influence each other and together they create different effects on the mind, but also on the immune system. Read on and learn everything about how THC and CBD work together.



The best-known cannabinoids are THC and CBD, you probably know that. THC is the substance that causes the high. CBD has made a tremendous advance in recent years. Studies show that CBD can help with the treatment of various disorders, such as chronic inflammation and fatigue. In addition, there are patients who indicate that CBD reduces anxiety and depressive feelings. But the list of medical conditions that CBD can help with is much longer. MS, epilepsy, fractures, neuropathic pain and anorexia are also conditions in which CBD can play a positive role. In the field of CBD, studies into the effects and the possible role in treatments are still needed. In other words: there is still a lot to discover about CBD.

What is the entourage effect?

You must have heard of it, the much-discussed entourage effect. When THC and CBD fuse together, this creates a magical reaction: the entourage effect. The entourage effect improves the positive properties of THC and CBD, see it as a win-win situation. For example, THC can cause anxiety and stress in some cases. But when it is mixed with CBD, many users experience much more relaxation and positive feelings. Negative symptoms of the one get canceled out by the traits of the other and vice versa. Isn’t that fantastic? CBD is the most common cannabinoid in cannabis, after THC. THC is also the best known and the best researched. The THC / CBD ratio can vary widely between different cannabis strains.

As indicated, the substances CBD and THC affect various cannabinoid receptors located in the human endocannabinoid system throughout the body. The endocannabinoid system (or ECS) has the main function of regulating various body functions. Some tasks that are scheduled under the endocannabinoid system are the regulation of cognition, the regulation of appetite, and nervousness. The body naturally produces cannabinoids. But these cannabinoids can also be supplemented with cannabinoids from outside, for example from the marijuana plant.

Receptors in the human body

CBD has an effect on natural cannabinoids and binds to some receptors that are responsible for physical and mental health. There are also CB2 receptors that occur in the brain. But these are not with as many as the other receptors. The receptors also regulate the immune system, this is a complex process, and they help to reduce and prevent digestive inflammatory responses.

How CBD and THC effect the brain

There is also a so-called binding affinity, this applies to the THC with the CB1 receptors. We will not make this a boring, sleep-inducing chemistry lesson. But it is interesting how substances from the cannabis plant work together with substances in the human body. That way you will appreciate the amazing cannabis plant even more! The receptors we are talking about are located in the brain, but also in the central nervous system (CNS), and even in the sex glands, and in  many other glands and organs. You can find them throughout the body. Did you know that these receptors ensure that you experience the euphoric, psychoactive feeling caused by THC? They are also responsible for reducing pain. CBD is non-psychoactive, it cannot make you high. But what CBD does is that it works with CB1 and CB2 receptors, and that is very bennificial for the immune system.

Different experiences

Different compositions provide different experiences. Many studies link the THC / CBD to the experience of being ‘high’. Medical marijuana usually contains more than 4% CBD and can be very positive for users who suffer from nervousness. This is because CBD manages to reduce the negative effects of THC. It is important to note that it varies considerably per person. After all, every person has a different biological system, and a certain substance that someone receives can turn out differently for someone else. There are no set criteria for this. There are also strains with a lot of THC, for example Haze. The THC percentage of this powerful strain can be as high as 20%. The presence of CBD (no matter how little) ensures that the possible negative effects of the strain are reduced. What remains are the positive effects of cannabis that is what we are all looking for!

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